Description

(±)-Methotrimeprazine (D6) is a deuterated isotopologue of the phenothiazine derivative methotrimeprazine, specifically labeled with six deuterium atoms. This compound is a critical analytical standard used as an internal standard for the precise quantification of methotrimeprazine in complex matrices via mass spectrometry. It is essential for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors who require high-fidelity reference materials for method development, validation, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable isotope-labeled internal standard for the accurate bioanalysis and pharmacokinetic study of methotrimeprazine.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for drug substance and drug product testing during formulation studies.
• Forensic and Clinical Toxicology: Enables precise measurement of methotrimeprazine concentrations in biological samples (e.g., plasma, urine) for diagnostic and legal purposes.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in metabolism studies.
• Quality Control & Assurance: Serves as a certified reference material (CRM) to ensure the accuracy and precision of in-house testing methods in QC laboratories.
• Regulatory Submissions: Supports data packages submitted to agencies like the FDA and EMA by providing traceable and reliable quantification data.

Basic Information

Product Name	(±)-Methotrimeprazine (D6)
CAS No.	1189805-51-3
Molecular Formula	C19H18D6N2OS
Molecular Weight	334.51 g/mol
Synonyms	Levomepromazine-d6; Methotrimeprazine-d6; 2-Methoxy-10-[2-(1-methyl-2-piperidinyl)ethyl]phenothiazine-d6; (±)-Levomepromazine-d6; 7043-D6; Nozinan-d6; Neurocil-d6; Contemnol-d6
EINECS	Contact for details

Quality Control

Every batch of (±)-Methotrimeprazine (D6) CAS NO 1189805-51-3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data including HPLC purity, isotopic enrichment (D-content), and confirmation of structure by NMR and MS. A detailed Certificate of Analysis (COA) specifying batch-specific results is supplied with each shipment, ensuring full traceability and compliance with research and quality control standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.