Description

n-Desmethyl Zopiclone-D8 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units requiring precise measurement of its parent drug and metabolites.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of zopiclone and its metabolites in biological matrices.
• Pharmacokinetic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic Toxicology: Used in confirmatory testing and method development for the detection of zopiclone in forensic and workplace drug testing.
• Drug Metabolism Research: Facilitates the identification and quantification of specific metabolic pathways by providing a non-interfering reference signal.
• Bioanalytical Method Development: A key component in validating robust, sensitive, and specific analytical methods according to FDA and EMA guidelines.
• Reference Standard Manufacturing: Used by certified suppliers as a primary reference material to calibrate and qualify working standards.

Basic Information

Product Name	n-Desmethyl Zopiclone-D8 Hydrochloride
CAS No.	1189719-74-1
Molecular Formula	C16H8D8ClN6O3•HCl
Molecular Weight	409.78 g/mol
Synonyms	6-(5-Chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-4(4aH)-one-d8 Desmethyl Hydrochloride; Zopiclone N-Desmethyl-D8 Hydrochloride; Zopiclone Metabolite D8 Hydrochloride; 2-(5-Chloro-2-pyridinyl)-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraene-1,3-dione-d8 Desmethyl Hydrochloride; Desmethylzopiclone-d8 HCl; (RS)-6-(5-Chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-4(4aH)-one-d8 Desmethyl Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Zopiclone-D8 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the stringent requirements for use as an internal standard. Our quality system ensures traceability and consistency. Comprehensive Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, isotopic purity (D-enrichment), and residual solvent analysis are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.