Description

Dibenzazepinone-D4 is a deuterated analog of the dibenzazepinone core structure, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of non-labeled dibenzazepinone or related active pharmaceutical ingredients (APIs).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying parent drugs and metabolites in biological matrices (e.g., plasma, urine) during preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Enables the creation of robust, precise, and accurate analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products in drug substances and products.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques that require isotope-labeled compounds for absolute quantification.

Basic Information

Item	Detail
Product Name	Dibenzazepinone-D4
CAS No.	1189706-86-2
Molecular Formula	C15H8D4N2O
Molecular Weight	~236.28 g/mol
Synonyms	5H-Dibenzo[b,e][1,4]diazepin-11(10H)-one-D4; 10,11-Dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one-D4; Dibenz[b,e][1,4]oxazepin-11(10H)-one-D4 (structural isomer check); Deuterated Dibenzazepinone; Dibenzazepinone-d4; [2H4]-Dibenzazepinone
EINECS	Contact for details

Quality Control

Our Dibenzazepinone-D4 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D4, D3, D2), chemical purity, and analytical data is provided and available upon request to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.