Description

Metoprolol Acid-D5 Ethyl Ester CAS NO 1189704-28-6 is a high-purity, deuterium-labeled derivative of a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on cardiovascular drug development and regulatory compliance.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of Metoprolol and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Critical component in bioanalytical method development and validation for clinical and preclinical studies of β-blocker therapeutics.
• Enables accurate pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies by correcting for matrix effects and instrument variability.
• Supports doping control analysis in sports medicine for the detection of β-blockers.
• Used in forensic toxicology investigations for the definitive identification and measurement of Metoprolol.
• Facilitates drug metabolism research to elucidate metabolic pathways and identify potential drug-drug interactions.
• Serves as a high-purity chemical reference standard for quality control in API manufacturing.
• Essential for regulatory submissions to agencies like the FDA and EMA, where validated analytical methods are required.

Basic Information

Product Name	Metoprolol Acid-D5 Ethyl Ester
CAS No.	1189704-28-6
Molecular Formula	C15H20D5NO4
Molecular Weight	Contact for details
Synonyms	1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol Acid-D5 Ethyl Ester
Metoprolol Related Compound D5 Ethyl Ester
Metoprolol Carboxylic Acid-D5 Ethyl Ester
Metoprolol Acid Ethyl Ester-d5
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, propanoate-d5
Deuterated Metoprolol Acid Ethyl Ester
Metoprolol-D5 Ethyl Ester Intermediate
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity, which are critical for accurate mass spectrometry. Each batch is analyzed using advanced techniques including NMR (for deuterium incorporation) and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment, and impurity profiles. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.