Description

Ifosfamide-D4 is a deuterated analog of the widely used antineoplastic agent, Ifosfamide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of oncology therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of Ifosfamide in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a reference compound to establish and validate robust, sensitive, and specific analytical assays in compliance with GLP and FDA/EMA guidelines.
• Pharmaceutical Quality Control: Used in impurity profiling and assay development to ensure the purity and potency of Ifosfamide drug substances and products.
• Metabolite Identification: Aids in the structural elucidation and quantification of Ifosfamide metabolites using advanced mass spectrometry techniques.

Basic Information

Product Name	Ifosfamide-D4
CAS No.	1189701-13-0
Molecular Formula	C7H11D4Cl2N2O2P
Molecular Weight	266.10 g/mol (deuterated form)
Synonyms	3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide-d4; Ifosfamide (tetradeuterated); Ifosfamide-d4; Isofosfamide-d4; Ifex-d4; Holoxan-d4; Deuterated Ifosfamide; Isotopic Labeled Ifosfamide
EINECS	Contact for details

Quality Control

Our Ifosfamide-D4 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. We guarantee chemical purity ≥98% and isotopic enrichment ≥99% D, making it suitable for the most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.