Description

Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonamido)Pyrimidine-5-Carboxylate-D6 is a high-purity deuterated pyrimidine derivative, serving as a critical stable isotope-labeled intermediate. Its primary value lies in enabling advanced pharmacokinetic and metabolic studies, providing essential data for drug development and regulatory submissions. This compound is specifically designed for use by pharmaceutical R&D teams, analytical laboratories, and contract research organizations (CROs) engaged in the synthesis and analysis of deuterated drug substances and their metabolites.

Application

• Deuterated Pharmaceutical Intermediate: A key building block for the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and study drug mechanisms.
• Internal Standard for Mass Spectrometry: Used as a quantitative internal standard in LC-MS/MS and GC-MS bioanalytical methods for accurate drug quantification in biological matrices.
• Metabolite Identification & Tracing: Facilitates the identification and tracking of drug metabolites in Absorption, Distribution, Metabolism, and Excretion (ADME) studies.
• Isotope Dilution Analysis: Enables precise quantification in complex mixtures through isotope dilution techniques in analytical chemistry.
• Research Chemical for Medicinal Chemistry: Supports structure-activity relationship (SAR) studies by providing a deuterated analog for investigating isotope effects.
• Reference Standard: Serves as a certified reference material (CRM) for method validation and quality control in regulatory-compliant laboratories.

Basic Information

Item	Detail
Product Name	Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonamido)Pyrimidine-5-Carboxylate-D6
CAS No.	1189696-04-5
Molecular Formula	C₁₈H₁₉D₆FN₂O₄S
Molecular Weight	Contact for details
Synonyms	Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methylmethanesulfonamido)pyrimidine-5-carboxylate-d6; Deuterated Pyrimidine Carboxylate Derivative; 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methylsulfamoyl)methyl]pyrimidine-5-carboxylic acid ethyl ester-d6; (D6)-Labeled Pyrimidine Sulfonamide Ester; 1189696-04-5; Ethyl 4-(p-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate-d6; Deuterated Sulfonamido Pyrimidine Ester
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (D-content), chemical purity, and identity confirmation, supporting use in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and stored in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.