Description

Oxyphenbutazone-D9 is a deuterium-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) oxyphenbutazone, where nine hydrogen atoms are replaced by the stable isotope deuterium. This compound is a critical tool for quantitative bioanalytical research, providing an essential internal standard for mass spectrometry to ensure accurate pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing.

Application

• As a stable isotope-labeled internal standard for the precise quantification of oxyphenbutazone in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• In drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• For the development and validation of robust bioanalytical methods in compliance with FDA, EMA, and ICH guidelines.
• In clinical research to monitor drug concentrations in patient samples during therapeutic drug monitoring (TDM) or clinical trials.
• Supporting forensic and toxicological analysis for the accurate detection and measurement of oxyphenbutazone and its metabolites.
• Used in pharmaceutical quality control laboratories for reference and calibration purposes in method development.

Basic Information

Product Name	Oxyphenbutazone-D9
CAS No.	1189693-23-9
Molecular Formula	C19H11D9N2O2
Molecular Weight	Approx. 327.40 g/mol
Synonyms	1-Phenyl-2-(4-hydroxy-3,5-dideuteriophenoxy)-4-butyl-3,5-dideuterio-1H-pyrazolidine-3,5-dione-d5; 4-Butyl-1-phenyl-3,5-dioxo-2-(4-hydroxy-3,5-dideuteriophenoxy)pyrazolidine-d5; Deuterated Oxyphenbutazone; [D9]-Oxyphenbutazone; Oxyphenbutazone d9; Oxyphenbutazone (phenyl-d5, butyl-d4); Tanderil-d9
EINECS	Contact for details

Quality Control

Our Oxyphenbutazone-D9 is manufactured under strict quality systems to ensure high chemical and isotopic purity, essential for reliable analytical results. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for purity, isotopic enrichment, and residual solvents, supporting compliance with GLP and ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.