Description

5-Carboxy Tolterodine-D14 Formate is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and related techniques, where it compensates for matrix effects and instrumental variability. It is an essential tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units involved in the pharmacokinetic study, metabolism research, and impurity profiling of Tolterodine and its related substances.

Application

• LC-MS/MS Internal Standard: Primary application as a stable isotope-labeled internal standard for the precise quantification of Tolterodine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables accurate measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Metabolite Identification & Profiling: Used in high-resolution mass spectrometry to identify and quantify oxidative and other metabolic pathways of Tolterodine.
• Method Development & Validation: Serves as a critical component in developing and validating robust, GLP/GMP-compliant analytical methods for regulatory submissions.
• Doping Control & Forensic Analysis: Applicable in sports anti-doping and forensic toxicology for the definitive identification and quantification of Tolterodine.
• Quality Control & Impurity Testing: Supports the analysis of potential genotoxic impurities and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	5-Carboxy Tolterodine-D14 Formate
CAS No.	1189681-84-2
Molecular Formula	C26H24D14N2O5
Molecular Weight	Contact for details
Synonyms	(R)-N,N-Diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine-2,2,3,3-D4-1,1,1,2,2,3,3,4,4,5,5,6,6,6-D14 Carboxylic Acid Formate Salt; Tolterodine-d14 Carboxylic Acid Formate; Tolterodine-2,2,3,3-D4-1,1,1,2,2,3,3,4,4,5,5,6,6,6-D14-5-Carboxylic Acid Formate; Deuterated Tolterodine Acid Metabolite Standard; 5-Carboxy Tolterodine-d14; 5-COOH Tolterodine-D14 Formate
EINECS	Contact for details

Quality Control

Every batch of 5-Carboxy Tolterodine-D14 Formate is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.