Description

Remifentanil-13C6 Hydrochloride is a stable isotope-labeled analog of the potent, ultra-short-acting opioid analgesic remifentanil, specifically designed for use as an internal standard in quantitative mass spectrometry. This high-purity reference material is critical for ensuring analytical accuracy and reproducibility in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations engaged in precise drug quantification and method validation.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of remifentanil and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug concentration-time profiles to study absorption, distribution, metabolism, and excretion (ADME).
• Forensic and Clinical Toxicology: Used in confirmatory testing and method development for the detection and quantification of remifentanil in forensic and clinical settings.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite formation pathways.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods according to GLP and FDA/EMA guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be used in impurity profiling and assay development for drug substance and product testing.

Basic Information

Product Name	Remifentanil-13C6 Hydrochloride
CAS No.	1189679-87-5
Molecular Formula	C20H28N2O5•HCl (with six 13C atoms)
Molecular Weight	~413.9 g/mol (13C6 labeled)
Synonyms	Remifentanil-13C6 HCl; 1-(2-Methoxycarbonyl-ethyl)-4-(phenyl-propanoyl-oxido)-piperidine-3-carboxylic acid methyl ester-13C6 hydrochloride; GI87084B-13C6; Ultiva-13C6 (labeled analog); Methyl 1-(3-methoxy-3-oxopropyl)-4-(phenylpropanoyl)oxy-4-piperidinecarboxylate-13C6 hydrochloride; 3-[4-Methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1-piperidine]propanoic acid methyl ester-13C6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Remifentanil-13C6 Hydrochloride is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing results for identity, purity (by HPLC), isotopic enrichment, and related substances. Our quality commitment ensures compliance with the standards required for GLP and GMP research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Enrichment	≥99 atom % 13C (at labeled positions)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.