Description

4'-Hydroxyphenylcarvedilol-D3 is a deuterated analog of a carvedilol metabolite, specifically designed for use as a high-purity internal standard in quantitative bioanalytical methods. This compound is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies by correcting for variations in sample preparation and instrument analysis. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of carvedilol and its metabolites in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track and measure the metabolic pathway and clearance rates of carvedilol in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical reference material for developing, optimizing, and validating robust analytical methods compliant with FDA and ICH guidelines.
• Clinical Trial Support: Enables accurate therapeutic drug monitoring and exposure-response analysis during clinical phases of drug development.
• Reference Standard for Impurity Testing: Can be utilized as a characterized reference material for identifying and quantifying specific metabolite-related impurities in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	4'-Hydroxyphenylcarvedilol-D3
CAS No.	1189675-28-2
Molecular Formula	C24H23D3N2O5
Molecular Weight	425.50 g/mol (for deuterated form)
Synonyms	1-(Carbazol-4-yloxy)-3-[[2-(2-deuteriomethoxy-3,4,5,6-tetradeuteriophenoxy)ethyl]amino]-2-propanol-D3; Carvedilol D3 Metabolite; Carvedilol Hydroxy Phenyl D3; 4'-HP-Carvedilol-D3; Deuterated 4'-Hydroxy Carvedilol; [2H3]-4'-Hydroxyphenylcarvedilol; Internal Standard for Carvedilol Metabolite
EINECS	Contact for details

Quality Control

Every batch of 4'-Hydroxyphenylcarvedilol-D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, LC-MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, deuterium enrichment, and absence of critical impurities. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.