Description

Amoxapine-D8 is a deuterium-labeled analog of the tricyclic antidepressant amoxapine, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS/MS) analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for method development, validation, and precise pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS quantification of amoxapine in biological matrices (plasma, serum, urine).
• Metabolite identification and profiling studies in drug metabolism and pharmacokinetics (DMPK).
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs).
• Forensic analysis and clinical toxicology for the accurate detection of amoxapine.
• Stability-indicating assay development for pharmaceutical formulations.
• Use in isotope dilution mass spectrometry (IDMS) for achieving the highest analytical precision.

Basic Information

Product Name	Amoxapine-D8
CAS No.	1189671-27-9
Molecular Formula	C17H8D8ClN2O
Molecular Weight	316.85 g/mol
Synonyms	2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine-d8; Amoxapine-d8; Deuterated Amoxapine; Amoxapine (phenyl-d5, piperazine-d3); Amoxapine Internal Standard; 8-Deutero-amoxapine; Loxapine related compound D (deuterated)
EINECS	Contact for details

Quality Control

Our Amoxapine-D8 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical stability. Each batch is accompanied by comprehensive analytical documentation, including Certificates of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (by HPLC, typically ≥98%), and identity confirmation. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of GLP/GMP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.