Description

Dapsone Hydroxylamine-D8 (Major) is a high-purity, deuterium-labeled isotopologue of a key pharmaceutical intermediate. This compound is essential for advanced analytical applications, providing a stable internal standard for precise quantification and metabolic pathway elucidation in complex biological matrices. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in pharmacokinetic studies, drug metabolism research (DMPK), and the development of bioanalytical methods for dapsone and related compounds.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the accurate quantification of dapsone and its metabolites in plasma, serum, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables detailed studies on the absorption, distribution, metabolism, and excretion (ADME) profile of dapsone, facilitating a clearer understanding of its biotransformation pathways.
• Stable Isotope Dilution Assays: Used in high-precision assays where deuterium labeling minimizes matrix effects and improves analytical accuracy and reproducibility in complex samples.
• Pharmaceutical R&D: Supports method development and validation in the research and development of new sulfone-based therapeutics, ensuring regulatory compliance for bioanalytical data.
• Forensic and Clinical Toxicology: Aids in the specific and sensitive detection and confirmation of dapsone in forensic analysis and clinical overdose scenarios.

Basic Information

Product Name	Dapsone Hydroxylamine-D8 (Major)
CAS No.	1189668-47-0
Molecular Formula	C12H5D8N2O2S
Molecular Weight	~257.35 g/mol
Synonyms	4,4'-Sulfonylbis(aniline)-N-hydroxy-D8; Dapsone Hydroxylamine-d8; Dapsone N-Hydroxy-d8; 4-Amino-4'-hydroxylaminodiphenyl sulfone-d8; 4,4'-Diaminodiphenyl sulfone hydroxylamine-d8; DDS Hydroxylamine-d8; Dapsone Hydroxylamine (Major, deuterated); Deuterated Dapsone Hydroxylamine
EINECS	Contact for details

Quality Control

Every batch of Dapsone Hydroxylamine-D8 (Major) is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (HPLC), isotopic enrichment (D-content), and other critical parameters to ensure consistency and reliability for your sensitive analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.