Description

3-Hydroxymethyl Meclofenamic Acid-D4 is a deuterated derivative of the non-steroidal anti-inflammatory drug (NSAID) meclofenamic acid, specifically labeled at the hydroxymethyl position. This compound is a critical internal standard for the precise quantification of meclofenamic acid and its metabolites in complex biological matrices using mass spectrometry. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, enabling accurate pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Reference Standard: Serves as a stable isotope-labeled internal standard for the accurate quantification of meclofenamic acid in LC-MS/MS and GC-MS assays.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for drug substance and product testing.
• Forensic & Doping Analysis: Supports accurate detection and confirmation of meclofenamic acid in forensic toxicology and anti-doping control.
• Biomarker Research: Facilitates the study of inflammatory pathways and related biomarkers where meclofenamic acid is used as a pharmacological probe.

Basic Information

Product Name	3-Hydroxymethyl Meclofenamic Acid-D4
CAS No.	1189663-45-3
Molecular Formula	C15H9D4Cl2NO3
Molecular Weight	318.19 g/mol (for D4 isotopologue)
Synonyms	Meclofenamic Acid D4 (Hydroxymethyl Labeled); 2-[(2,6-Dichloro-3-methylphenyl)amino]-3-(hydroxymethyl-d4)benzoic Acid; N-(2,6-Dichloro-m-tolyl)-3-(hydroxymethyl-d4)anthranilic Acid; Deuterated Meclofenamic Acid Hydroxymethyl; Meclofenamate-d4 (Hydroxymethyl); Internal Standard for Meclofenamic Acid; [D4]-3-Hydroxymethyl Meclofenamic Acid
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality control to ensure high isotopic purity and chemical integrity, essential for reliable analytical results. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and other critical specifications. We support compliance with GLP and ISO 17025 standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. For long-term storage, keep the container sealed under an inert atmosphere in a cool, dry place. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.