Description

5-(4-Ethoxyphenyl)-5-(Ethyl-D5)Barbituric Acid is a deuterated derivative of a barbiturate compound, serving as a crucial stable isotope-labeled internal standard for analytical chemistry. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analyses in complex matrices. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the precise quantification of its non-deuterated counterpart or related barbiturates in bioanalytical methods, correcting for matrix effects and instrument variability.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies, enabling accurate measurement of drug candidate concentrations in biological fluids.
• Forensic and Clinical Toxicology: Facilitates the reliable identification and quantification of barbiturate compounds in forensic investigations and clinical diagnostic assays.
• Method Development and Validation: A critical tool for developing, optimizing, and validating sensitive and specific analytical methods according to ICH, FDA, or other regulatory guidelines.
• Quality Control in Manufacturing: Employed in the quality control laboratories of pharmaceutical manufacturers to monitor potential impurities or degradation products.
• Metabolite Studies: Aids in the identification and quantification of drug metabolites in research focused on metabolic pathways.

Basic Information

Product Name	5-(4-Ethoxyphenyl)-5-(Ethyl-D5)Barbituric Acid
CAS No.	1189662-98-3
Molecular Formula	C14H11D5N2O4
Molecular Weight	279.31 g/mol
Synonyms	5-(4-Ethoxyphenyl)-5-(1,1,2,2,2-pentadeuteroethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(p-Ethoxyphenyl)-5-(ethyl-d5)barbituric acid; Deuterated 5-(4-Ethoxyphenyl)-5-ethylbarbituric Acid; 5-Ethyl-5-(4-ethoxyphenyl)barbituric Acid-d5; Ethyl-D5 Barbituric Acid Derivative; Stable Isotope Labeled Barbiturate; Internal Standard for Barbiturate Analysis
EINECS	Contact for details

Quality Control

Our 5-(4-Ethoxyphenyl)-5-(Ethyl-D5)Barbituric Acid is manufactured under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and/or MS for structural confirmation and isotopic purity (D-enrichment), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specifications and test results to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.