Description

Carebastine-D5 CAS NO 1189661-02-6 is a deuterated isotopologue of the active metabolite of the antihistamine ebastine, serving as a critical internal standard for precise quantitative analysis. This high-purity reference material is essential for ensuring accuracy and reliability in bioanalytical and pharmacokinetic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers involved in method development and validation for drug metabolism and stability testing.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of ebastine and carebastine in biological matrices.
• Method development and validation for pharmacokinetic (PK) and bioequivalence studies in clinical research.
• High-accuracy calibration in drug metabolism and disposition (DMPK) investigations to track metabolite profiles.
• Quality control and assurance in the manufacturing of pharmaceutical actives requiring stringent impurity profiling.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing definitive analytical data.
• Use in stable isotope dilution analysis to correct for analyte loss during complex sample preparation.

Basic Information

Product Name	Carebastine-D5
CAS No.	1189661-02-6
Molecular Formula	C26H34D5NO3
Molecular Weight	~ 419.62 g/mol
Synonyms	Carebastine-d5; 4-(4-Benzyldioxan-4-yl)-1-[4-(1,1,2,2,2-pentadeuteriophenyl)butyl]piperidine; Ebastine Metabolite-d5; 1-[4-(Pentadeuteriophenyl)butyl]-4-(4-benzhydryl-1,4-dioxanyl)piperidine; (±)-Carebastine-d5; BAY cx 659-d5; RP 64305-d5
EINECS	Contact for details

Quality Control

Every batch of Carebastine-D5 is manufactured and controlled under a strict quality management system. It undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, chemical purity, and isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment ensures the material meets the exacting standards required for GLP/GMP-compliant research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.