Description

2-Hydrazino-α-(4-Hydroxy-3-methoxybenzyl)propionitrile-D5 is a deuterated isotopologue of a key intermediate used in the synthesis of complex organic molecules. This compound matters for its role in enabling advanced research and development, particularly in the creation of deuterium-labeled pharmaceuticals and analytical standards. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, metabolism studies, and high-precision analytical method development.

Application

• Pharmaceutical Research: Critical intermediate for synthesizing deuterium-labeled drug candidates and metabolites for pharmacokinetic and pharmacodynamic studies.
• Analytical Chemistry: Used as an internal standard in quantitative mass spectrometry (LC-MS/MS, GC-MS) to ensure accuracy and precision in bioanalytical assays.
• Metabolism Studies: Enables the tracing of metabolic pathways and the identification of drug metabolites in biological systems.
• Stable Isotope Labeling: Serves as a building block for incorporating deuterium atoms into target molecules to alter physical, chemical, or metabolic properties.
• Process Chemistry Development: Used in route scouting and optimization for the synthesis of complex active pharmaceutical ingredients (APIs).
• Reference Standard Production: Manufactured to high purity for use as certified reference materials (CRMs) in regulated laboratories.

Basic Information

Product Name	2-Hydrazino-α-(4-Hydroxy-3-methoxybenzyl)propionitrile-D5
CAS No.	1189658-77-2
Molecular Formula	C11H8D5N3O2
Molecular Weight	~224.26 g/mol
Synonyms	2-Hydrazinyl-2-(4-hydroxy-3-methoxyphenyl)-3,3,4,4,5,5,5-heptadeuteriopentanenitrile; 2-Hydrazino-α-(4-Hydroxy-3-methoxybenzyl)propionitrile-d5; 2-(4-Hydroxy-3-methoxyphenyl)-2-hydrazinyl-3,3,4,4,5,5,5-heptadeuteriopentanenitrile; Deuterated 2-Hydrazino-α-Vanillylpropionitrile; 2-Hydrazino-α-(4-Hydroxy-3-methoxybenzyl)propionitrile (pentadeuterated); D5-2-Hydrazino-α-(4-Hydroxy-3-methoxybenzyl)propionitrile
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR and mass spectrometry to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment, purity, and identity are provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.