Description

Terbutaline-D9 is a deuterated isotopologue of the β-2 adrenergic agonist terbutaline, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, where it corrects for variations in sample preparation and instrument response. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug metabolism, pharmacokinetic (PK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of terbutaline in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable-isotope dilution assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of terbutaline.
• Bioanalytical Method Development and Validation: Serves as a reference compound to establish selectivity, sensitivity, accuracy, and precision of analytical methods for regulatory submission.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables accurate measurement of terbutaline concentrations in patient samples to optimize dosing regimens.
• Forensic and Doping Control Analysis: Employed in confirmatory testing for the detection of β-2 agonist misuse in sports or forensic toxicology.
• Pharmaceutical Quality Control: Can be used in impurity profiling and assay development for terbutaline-containing drug products.

Basic Information

Product Name	Terbutaline-D9
CAS No.	1189658-09-0
Molecular Formula	C12H10D9NO3
Molecular Weight	229.31 g/mol
Synonyms	Terbutaline-d9; (RS)-Terbutaline-d9; 1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol-d9; 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol-d9; (±)-Terbutaline-d9; Bricanyl-d9; Brethine-d9; KWD-2019-d9
EINECS	Contact for details

Quality Control

Our Terbutaline-D9 is manufactured under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.