Description

Clofibrate-D4 is a stable isotope-labeled analog of the lipid-regulating agent clofibrate, where four hydrogen atoms are replaced by deuterium. This high-purity internal standard is critical for ensuring the accuracy and reliability of quantitative mass spectrometry-based analyses in pharmaceutical and metabolic research. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring precise bioanalytical measurements.

Application

• Quantitative Bioanalysis: Serves as a deuterated internal standard for the precise quantification of clofibrate and its metabolites in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic & Metabolic Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Disposition (DMPK): Used to study metabolic pathways and to correct for analyte loss during sample preparation and instrument analysis.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of clofibrate in active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic & Anti-Doping Analysis: Provides a reliable reference for the detection and confirmation of clofibrate in forensic toxicology and sports doping control.
• Environmental Analysis: Can be utilized as a standard in methods developed to detect pharmaceutical residues in environmental water samples.

Basic Information

Product Name	Clofibrate-D4
CAS No.	1189654-03-2
Molecular Formula	C12H11D4ClO3
Molecular Weight	246.73 g/mol (for deuterated form)
Synonyms	Clofibrate-d4; 2-(4-Chlorophenoxy)-2-methylpropanoic Acid Ethyl-d4 Ester; Ethyl-d4 2-(p-Chlorophenoxy)-2-methylpropionate; Ethyl 2-(4-Chlorophenoxy)-2-methylpropionate-d4; Deuterated Clofibrate; Clofibrate Internal Standard; Atromid-S-d4; Liprinal-d4
EINECS	Contact for details

Quality Control

Every batch of Clofibrate-D4 is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, MS, and HPLC. A Certificate of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and impurity profile is provided with each shipment to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 98.0 atom % D (by MS)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.