Description

Citalopram-D6 n-Oxide CAS NO 1189652-54-7 is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy and regulatory compliance in pharmaceutical research and development. This stable isotope-labeled compound is specifically designed for use in quantitative mass spectrometry, providing unmatched precision for pharmacokinetic and metabolic studies. It is an essential tool for analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories who require reliable reference materials for method development and validation.

Application

• Quantitative Bioanalysis: Serves as a deuterated internal standard in LC-MS/MS and GC-MS methods for the precise quantification of citalopram and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Metabolite Identification and Profiling: Used as a reference standard to identify and characterize oxidative metabolites of citalopram, aiding in drug safety assessment.
• Method Development and Validation: A critical component for developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of citalopram in forensic investigations and toxicology screenings.

Basic Information

Product Name	Citalopram-D6 n-Oxide
CAS No.	1189652-54-7
Molecular Formula	C20H15D6FN2O2
Molecular Weight	341.41 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(trideuteriomethyl)isobenzofuran-D3-8-carbonitrile N-Oxide; Citalopram D6 N-Oxide; Citalopram-d6 N-Oxide; Deuterated Citalopram N-Oxide; Citalopram N-Oxide-d6; 1,3-Dihydro-5-[methyl-d3]-1-[4-(trifluoromethyl)phenoxy]isobenzofuran-8-carbonitrile-d3 N-Oxide (Related structure); Celexa-d6 N-Oxide (Labeled Metabolite Standard)
EINECS	Contact for details

Quality Control

Every batch of Citalopram-D6 n-Oxide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the highest industry standards for isotopic purity and chemical identity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are provided and are available upon request to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.