Description

Rac Demethyl Citalopram-D3 Hydrochloride is a deuterated isotopologue of a key citalopram metabolite, specifically designed for analytical and research applications. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative bioanalytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetic (DMPK) studies, forensic toxicology, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of citalopram and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in research to investigate the metabolic pathways, pharmacokinetics, and bioavailability of citalopram and related compounds.
• Forensic and Clinical Toxicology: Enables accurate measurement of citalopram levels for therapeutic drug monitoring (TDM), overdose cases, and forensic investigations.
• Method Development and Validation: A vital tool for developing, optimizing, and validating robust bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Pharmaceutical Quality Control: Can be used in impurity profiling and stability studies of citalopram drug substances and products.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy quantification techniques due to its nearly identical chemical properties with the analyte of interest.

Basic Information

Product Name	Rac Demethyl Citalopram-D3 Hydrochloride
CAS No.	1189650-18-7
Molecular Formula	C19H17D3FNO•HCl
Molecular Weight	341.85 g/mol (for free base C19H17D3FNO)
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-5-phthalancarbonitrile-D3 Hydrochloride; Desmethylcitalopram-D3 HCl; N-Desmethylcitalopram-D3 Hydrochloride; Didesmethylcitalopram-D3 Hydrochloride; Citalopram Metabolite D3 Hydrochloride; (RS)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Rac Demethyl Citalopram-D3 Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes comprehensive analysis, including HPLC for chemical purity, NMR and MS for structural confirmation, and determination of isotopic purity (D-content). A detailed Certificate of Analysis (COA) is provided, documenting all critical parameters to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.