Description

8-Methoxy Loxapine-D3 is a deuterium-labeled analog of a key pharmaceutical intermediate, specifically designed for advanced research and development applications. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 8-Methoxy Loxapine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Supports method development and validation in drug discovery and development pipelines for antipsychotic agents.
• Metabolite Profiling: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to track and identify drug metabolites.
• Bioanalytical Assays: Enhances the accuracy and reproducibility of high-throughput screening and clinical trial sample analysis.
• Forensic Toxicology: Aids in the definitive identification and quantification of substances in forensic investigations.
• Reference Material: Serves as a high-purity certified reference material (CRM) for calibrating analytical instrumentation.

Basic Information

Product Name	8-Methoxy Loxapine-D3
CAS No.	1189647-48-0
Molecular Formula	C₁₈H₁₅D₃ClN₂O₂
Molecular Weight	334.81 g/mol
Synonyms	8-Methoxy Loxapine-d3; Loxapine 8-Methyl Ether-d3; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepine-8-methoxy-d3; Deuterated 8-Methoxy Loxapine; 8-OMe Loxapine-d3; Loxapine Derivative-d3; 1189647-48-0; 8-Methoxy-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine-2-carbonitrile-d3
EINECS	Contact for details

Quality Control

Every batch of 8-Methoxy Loxapine-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting standards of analytical and research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity (by HPLC), isotopic enrichment, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D3)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.