Description

Acebutolol-D5 is a deuterated internal standard of the β-blocker Acebutolol, specifically designed for analytical applications. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry, particularly in pharmaceutical research and bioanalytical studies. It is a critical tool for scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors who require precise quantification of Acebutolol and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalysis.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of Acebutolol absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in the analysis of drug substance and finished product to ensure potency and purity.
• Forensic and Clinical Toxicology: Facilitates the precise measurement of Acebutolol levels in biological matrices for diagnostic or legal purposes.
• Method Development and Validation: Serves as a key component in developing and validating robust, regulatory-compliant analytical methods.
• Stable Isotope Dilution Analysis (SIDA): Employed in this highly accurate technique to correct for analyte loss during sample preparation and matrix effects.

Basic Information

Product Name	Acebutolol-D5
CAS No.	1189500-68-2
Molecular Formula	C18H23D5N2O4
Molecular Weight	339.45 g/mol (approximate)
Synonyms	N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide-d5; (±)-Acebutolol-d5; 3'-Acetyl-4'-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide-d5; Sectral-d5; Prent-d5; M&B 17803A-d5
EINECS	Contact for details

Quality Control

Our Acebutolol-D5 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch undergoes comprehensive analysis, including NMR and mass spectrometry, to confirm deuteration level and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications for identity, purity (by HPLC), isotopic enrichment, and other critical parameters to support your regulatory submissions and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.