Description

α-Carboline-15N2 n-Oxide is a stable isotope-labeled derivative of the β-carboline alkaloid class, specifically labeled with two nitrogen-15 atoms. This compound is of significant value as a critical internal standard and tracer in advanced analytical and metabolic research, ensuring precise quantification and pathway elucidation. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and the development of analytical methods for complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of β-carboline analogs and related metabolites in bioanalytical assays, correcting for matrix effects and instrument variability.
• Metabolic Pathway Tracer: Used in in vitro and in vivo studies to track the biotransformation and distribution of carboline-based compounds using mass spectrometry.
• Pharmaceutical Reference Standard: Serves as a certified reference material for method development, validation, and quality control in drug discovery and development pipelines.
• Neurochemical Research: Employed in studies investigating the role of endogenous β-carbolines in neurological processes and their interactions with receptors like benzodiazepine sites.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-precision IDMS protocols for achieving definitive measurements in clinical and forensic toxicology.

Basic Information

Product Name	α-Carboline-15N2 n-Oxide
CAS No.	1189496-03-4
Molecular Formula	C11H815N2O
Molecular Weight	186.19 g/mol (for 15N2 labeled form)
Synonyms	9H-Pyrido[2,3-b]indole-15N2 N-Oxide; Norharman-15N2 N-Oxide; β-Carboline-15N2 1-Oxide; 9H-Pyrido[3,4-b]indole-15N2 N-Oxide; Azafluorenone N-Oxide-15N2; 1-Aza-9-oxafluorene-15N2 derivative; Isotopically Labeled β-Carboline N-Oxide
EINECS	Contact for details

Quality Control

Every batch of α-Carboline-15N2 n-Oxide is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and MS for isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality system supports compliance with cGMP standards for use as a reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (MS)	≥98 atom % 15N
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.