Description

n-Desmethyl Loperamide-D3 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units requiring precise and sensitive detection methods for loperamide and its metabolites.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate quantification of loperamide and its metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic & Clinical Toxicology: Used in method development and validation for the sensitive detection and confirmation of loperamide in forensic and diagnostic testing.
• Drug Metabolism Research: Facilitates the study of metabolic pathways and the identification of specific metabolites in pharmaceutical development.
• Method Development & Validation: Provides a stable isotopic reference for developing robust, compliant analytical methods according to ICH, FDA, and EMA guidelines.
• Quality Control in Reference Material Production: Acts as a key component in the formulation and certification of certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	n-Desmethyl Loperamide-D3
CAS No.	1189488-17-2
Molecular Formula	C28H30D3ClN2O2
Molecular Weight	460.06 g/mol (approximate)
Synonyms	4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide-D3 (Desmethyl); Loperamide N-Desmethyl-D3; Loperamide Metabolite M1-D3; Loperamide-d3 Desmethyl Analog; [D3]-N-Desmethyl Loperamide; 4-Hydroxy Loperamide-D3; Loperamide Impurity D3
EINECS	Contact for details

Quality Control

Our n-Desmethyl Loperamide-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for use as an analytical reference standard. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chemical Purity	≥ 95.0%
Isotopic Enrichment (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.