Description

4-Amino-2,3,5,6-Tetradeuterio-n-(5-Methoxypyrimidin-2-Yl)Benzenesulfonamide is a deuterated sulfonamide derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a stable isotope-labeled internal standard, crucial for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in drug metabolism and pharmacokinetic (DMPK) studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutics, where precise bioanalytical measurement is non-negotiable.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by providing a stable isotopic marker that co-elutes with the analyte of interest.
• Pharmacokinetic (PK) and Bioanalytical Assay Development: Used to validate and calibrate high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) methods, improving assay robustness and regulatory compliance.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique for achieving high-precision quantitative analysis, minimizing matrix effects and instrumental variability.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants in active pharmaceutical ingredient (API) batches.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial sample analysis where the highest degree of quantitative accuracy is required.

Basic Information

Item	Detail
Product Name	4-Amino-2,3,5,6-Tetradeuterio-n-(5-Methoxypyrimidin-2-Yl)Benzenesulfonamide
CAS No.	1189483-96-2
Molecular Formula	C11H7D4N5O3S
Molecular Weight	285.33 g/mol
Synonyms	4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide-d4; Sulfameter-d4; Sulfamethoxydiazine-d4; 5-Methoxypyrimidine-2-sulfanilamide-d4; 2-(p-Aminobenzenesulfonamido)-5-methoxypyrimidine-d4; Deuterated Sulfameter; [2H4]-Sulfameter; Stable Isotope Labeled Sulfonamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management to ensure exceptional isotopic purity and chemical integrity, which is paramount for analytical applications. Each batch is characterized using advanced techniques including NMR (1H, 13C) and high-resolution mass spectrometry (HRMS) to confirm structure and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing specifications for chemical purity (typically ≥98% by HPLC), isotopic purity (≥98 atom % D), and residual solvent content. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccator or under an inert atmosphere after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 98%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.