Description

Elacridar-D4 is a deuterium-labeled analog of the potent P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) inhibitor, Elacridar. This stable isotope-labeled compound is essential for conducting advanced pharmacokinetic and metabolic studies, providing critical internal standards for mass spectrometry-based analytical methods. It is primarily used by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development, particularly for investigating drug-drug interactions and overcoming multidrug resistance in oncology.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantitative bioanalysis of Elacridar in biological matrices.
• Critical for conducting absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Facilitates drug-drug interaction studies by enabling precise measurement of P-gp/BCRP substrate pharmacokinetics.
• Supports research into overcoming multidrug resistance in cancer chemotherapy.
• Employed in the development and validation of regulatory-compliant bioanalytical methods for new drug applications.

Basic Information

Product Name	Elacridar-D4
CAS No.	1189481-51-3
Molecular Formula	C34H27D4F3N4O3
Molecular Weight	588.65 g/mol
Synonyms	N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl}-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide-d4; GF120918A-d4; GW120918A-d4; GG918-d4; Elacridar (tetradeuterated); Deuterated Elacridar; P-gp/BCRP Inhibitor-d4
EINECS	Contact for details

Quality Control

Our Elacridar-D4 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, essential for reliable analytical results. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and solvent content. We support research requiring compliance with GMP/GLP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.