Description

Clomipramine-D6 n-Oxide is a deuterium-labeled analog of the metabolite clomipramine N-oxide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in bioanalysis and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard for the precise measurement of clomipramine and its metabolites in complex biological matrices.
• Pharmacokinetic Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies for clomipramine.
• Metabolic Pathway Investigation: Used in research to elucidate and quantify the metabolic pathways of tricyclic antidepressants.
• Forensic and Clinical Toxicology: Supports the development and validation of highly specific and sensitive assays for drug monitoring and overdose cases.
• Method Development & Validation: Critical for developing, optimizing, and validating robust bioanalytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Reference Material Production: Serves as a calibrant or system suitability check in the production of certified reference materials.

Basic Information

Product Name	Clomipramine-D6 n-Oxide
CAS No.	1189479-06-8
Molecular Formula	C19H17D6ClN2O
Molecular Weight	334.88 g/mol (for unlabeled form, contact for exact deuterated mass)
Synonyms	3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine-D6 N-Oxide; Clomipramine D6 N-Oxide; Clomipramine-d6 N-Oxide; Deuterated Clomipramine N-Oxide; Clomipramine N-Oxide (hexadeuterated); Anafranil-D6 N-Oxide
EINECS	Contact for details

Quality Control

Every batch of Clomipramine-D6 n-Oxide is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and other critical parameters to ensure it meets the exacting standards required for analytical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.