Description

Loperamide-D6 is a deuterium-labeled analog of the anti-diarrheal agent Loperamide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical tool for pharmaceutical researchers, clinical laboratories, and forensic toxicologists engaged in drug metabolism studies, pharmacokinetic research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Primary use as a deuterated internal standard in the quantification of Loperamide and its metabolites in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Forensic and Clinical Toxicology: Supports accurate and legally defensible testing for Loperamide in forensic investigations and clinical overdose cases.
• Pharmaceutical R&D: Used in the development and validation of robust analytical methods for new drug formulations containing Loperamide.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring method compliance with regulatory guidelines (FDA, EMA).

Basic Information

Product Name	Loperamide-D6
CAS No.	1189469-46-2
Molecular Formula	C29H27D6ClN2O2
Molecular Weight	477.06 g/mol (approx.)
Synonyms	4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide-d6; Loperamide (hexadeuterated); Loperamide-d6; [2H6]-Loperamide; Loperamide Internal Standard; Loperamide-d6 (hexadeutero); 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide-d6
EINECS	Contact for details

Quality Control

Every batch of Loperamide-D6 is manufactured and analyzed under strict quality systems to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail parameters such as isotopic enrichment (Chemical Purity & Isotopic Purity), assay by HPLC, and identification by NMR and Mass Spectrometry. Our quality commitment aligns with the standards expected for pharmaceutical reference standards and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.