Description

Nalidixic Acid-D5 CAS NO 1189467-36-4 is a deuterated internal standard of the quinolone antibiotic nalidixic acid, where five hydrogen atoms are replaced with deuterium. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, environmental monitoring, and clinical diagnostics sectors for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a critical reference compound for the precise quantification of nalidixic acid and related quinolones in complex biological matrices.
• Pharmaceutical Research & Development: Facilitates pharmacokinetic studies, metabolism research, and bioanalytical method validation for antibiotic development.
• Food Safety & Veterinary Drug Residue Analysis: Enables accurate detection and measurement of antibiotic residues in food products, such as meat, milk, and honey, to ensure regulatory compliance.
• Environmental Monitoring: Applied in the analysis of water and soil samples to track the presence and concentration of pharmaceutical pollutants.
• Clinical Diagnostics: Supports therapeutic drug monitoring and clinical studies requiring high-sensitivity measurement of antibiotic levels.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites using advanced spectroscopic techniques.

Basic Information

Product Name	Nalidixic Acid-D5
CAS No.	1189467-36-4
Molecular Formula	C12H7D5N2O3
Molecular Weight	237.26 g/mol
Synonyms	1-Ethyl-1,4-dihydro-7-methyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic-2,5,6,7,8-d5 Acid; 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic-d5 Acid; Nalidixic-d5 Acid; Deuterated Nalidixic Acid; [2H5]-Nalidixic Acid; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic-d5 Acid
EINECS	Contact for details

Quality Control

Our Nalidixic Acid-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic methods, including NMR and Mass Spectrometry, to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.