Description

Trimethoprim-D9 Major is a high-purity, deuterium-labeled internal standard of the antibiotic Trimethoprim, specifically designed for analytical applications. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry, providing a critical tool for researchers and quality control laboratories. It is primarily used in pharmaceutical research, bioanalytical method development, and forensic toxicology for precise drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of Trimethoprim and its metabolites in complex biological matrices.
• Pharmaceutical R&D and DMPK Studies: Critical for drug metabolism and pharmacokinetic research, enabling precise tracking of drug absorption, distribution, metabolism, and excretion (ADME).
• Clinical and Forensic Toxicology: Used in method development and validation for the detection and quantification of Trimethoprim in human plasma, serum, or urine for therapeutic drug monitoring or forensic analysis.
• Veterinary Drug Residue Analysis: Applied in the development of analytical methods to monitor Trimethoprim residues in food-producing animals to ensure food safety and regulatory compliance.
• Environmental Analysis: Facilitates the trace-level detection and quantification of pharmaceutical pollutants, including Trimethoprim, in water and environmental samples.
• Reference Standard for Quality Control: Used as a certified reference material (CRM) or working standard in pharmaceutical quality control laboratories to verify assay methods and product purity.

Basic Information

Product Name	Trimethoprim-D9 Major
CAS No.	1189460-62-5
Molecular Formula	C14H9D9N4O3
Molecular Weight	299.38 g/mol
Synonyms	5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine-D9; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine-D9; Deuterated Trimethoprim (D9); Trimethoprim-d9; [D9]-Trimethoprim; TRIMP-d9; TMP-d9; Isotopically Labeled Trimethoprim
EINECS	Contact for details

Quality Control

Our Trimethoprim-D9 Major is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.