Description

Amodiaquine-D10 is a deuterated analog of the antimalarial drug amodiaquine, specifically labeled with ten deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and bioanalytical method validation.

Application

• Primary use as a stable isotope-labeled internal standard for the accurate quantification of amodiaquine and its metabolites in biological matrices (e.g., plasma, urine) via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioavailability studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of amodiaquine.
• Essential for bioanalytical method development and validation to ensure specificity, accuracy, and precision in drug concentration measurements.
• Used in drug metabolism research to track and identify metabolic pathways and potential drug-drug interactions.
• Serves as a high-purity certified reference material (CRM) for quality control and assurance in analytical laboratories.
• Applied in doping control analysis and forensic toxicology for the definitive identification of amodiaquine.

Basic Information

Product Name	Amodiaquine-D10
CAS No.	1189449-70-4
Molecular Formula	C₂₀H₁₂D₁₀ClN₃O
Molecular Weight	355.89 g/mol (deuterated form)
Synonyms	4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethyl-d10)amino]phenol; Amodiaquine-d10; Amodiaquine (phenyl-d5, diethyl-d5); Deuterated Amodiaquine; 2-[(Diethyl-d10)amino]-4-[(7-chloroquinolin-4-yl)amino]phenol; ASL 603-d10; Camoquin-d10 (labeled); NSC 3088-d10
EINECS	Contact for details

Quality Control

Every batch of Amodiaquine-D10 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic purity (atom % D), and chromatographic data. Our quality commitment ensures consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.