Description

3-Methoxy-n-Methyldesloratadine-D4 is a deuterated analog of a desloratadine derivative, serving as a crucial stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based methods, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the accurate quantification of 3-Methoxy-n-Methyldesloratadine and related metabolites in biological matrices.
• Pharmaceutical Research & Development: Critical for conducting definitive pharmacokinetic (PK), bioavailability, and bioequivalence studies during drug development.
• Metabolite Identification and Profiling: Aids in the structural elucidation and tracking of drug metabolites in in vitro and in vivo studies.
• Clinical Trial Support: Ensures data integrity and regulatory compliance in bioanalytical assays supporting clinical trials.
• Forensic and Doping Control Analysis: Provides high-specificity reference material for confirmatory testing in forensic toxicology and anti-doping laboratories.
• Quality Control in API Manufacturing: Supports impurity profiling and stability-indicating assay methods for active pharmaceutical ingredient (API) manufacturers.

Basic Information

Product Name	3-Methoxy-n-Methyldesloratadine-D4
CAS No.	1189445-21-3
Molecular Formula	C22H19D4ClN2O2
Molecular Weight	Contact for details
Synonyms	8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-3-carboxaldehyde-d4; Desloratadine D4 Derivative; 3-Formyl-11-(1-methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-8-carbonitrile-d4 (Methoxy derivative); Deuterated Desloratadine Metabolite Standard; 3-Methoxy-N-Methyl Desloratadine-d4; [D4]-3-Methoxy-n-Methyldesloratadine
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and High-Resolution Mass Spectrometry (HRMS). Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming structural identity. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.