Description

6-o-Desmethyl Donepezil-D5 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and development. This compound is specifically designed for use in mass spectrometry-based assays, providing superior precision and reliability for pharmacokinetic and metabolic studies. It is an essential analytical tool for pharmaceutical companies, contract research organizations (CROs), and academic laboratories focused on developing and validating bioanalytical methods for donepezil and its metabolites.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of donepezil and its metabolites in biological matrices.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to ensure accurate measurement of drug concentration over time.
• Essential for metabolite profiling and identification studies in drug metabolism and pharmacokinetics (DMPK) research.
• Used in the development and validation of regulatory-compliant bioanalytical methods supporting FDA and ICH submissions.
• Supports clinical trial research for Alzheimer's disease therapeutics by enabling precise drug monitoring.
• Applied in forensic and toxicological analysis for the accurate detection of donepezil.

Basic Information

Product Name	6-o-Desmethyl Donepezil-D5
CAS No.	1189443-74-0
Molecular Formula	C₂₄H₂₂D₅NO₃
Molecular Weight	388.52 g/mol
Synonyms	6-O-Desmethyl Donepezil-d5; Donepezil Metabolite 6-O-Desmethyl-d5; 1-Benzyl-4-[(5,6-dimethoxy-1-d₅-indan-2-yl)methyl]piperidine; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-d₅-indan-1-one; Aricept Metabolite-d5 (6-O-Desmethyl); E2020 Metabolite-d5
EINECS	Contact for details

Quality Control

Every batch of 6-o-Desmethyl Donepezil-D5 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic enrichment (by MS), and identity confirmation (by NMR and IR) is provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.