Description

1-Hydroxy-1,2-Dihydro Eprosartan-D3, Dimethyl Ester is a high-purity, deuterated derivative of the angiotensin II receptor antagonist eprosartan, specifically designed for advanced analytical and research applications. This compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards who require isotopically labeled compounds for mass spectrometry (LC-MS/MS).

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable isotope-labeled internal standard for the precise quantification of eprosartan and its metabolites in biological matrices like plasma and urine.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies, bioavailability/bioequivalence (BA/BE) testing, and clinical trial sample analysis.
• Reference Standard Manufacturing: Serves as a certified starting material or component for the preparation of high-grade pharmacopeial and working reference standards.
• Metabolic Pathway Investigation: Used in tracer studies to elucidate the detailed metabolic fate and biotransformation pathways of eprosartan.
• Method Development & Validation: Critical for developing, optimizing, and validating robust, regulatory-compliant analytical methods in bioanalytical laboratories.
• Quality Control in API Production: Employed in in-process control and final release testing to monitor impurities and ensure the quality of active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	1-Hydroxy-1,2-Dihydro Eprosartan-D3, Dimethyl Ester
CAS No.	1189431-71-7
Molecular Formula	C24H26D3N2O5S
Molecular Weight	460.59 g/mol
Synonyms	Eprosartan-D3 (1-Hydroxy-1,2-dihydro, dimethyl ester); (E)-3-[2-Carboxy-2-(thiophen-2-ylmethyl)prop-1-enyl]-4-d3-4-hydroxy-2-propyl-1H-imidazole-5-carboxylic Acid Dimethyl Ester; Deuterated Eprosartan Metabolite Standard; Eprosartan D3 Internal Standard; Eprosartan-d3 Dimethyl Ester; 1-Hydroxy-1,2-dihydroeprosartan-d3 dimethyl ester; SK&F-108566-D3 (dimethyl ester).
EINECS	Contact for details

Quality Control

Every batch of 1-Hydroxy-1,2-Dihydro Eprosartan-D3, Dimethyl Ester is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes identification, assay, and impurity profiling via advanced techniques like HPLC, LC-MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.