Description

Cycloguanil-D4 Hydrochloride is a deuterium-labeled analog of the active metabolite of the antimalarial drug proguanil. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical material for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors who require precise bioanalytical method development and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the analysis of cycloguanil and proguanil in biological matrices.
• Pharmacokinetic Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for antimalarial research.
• Bioanalytical Method Development: Used to validate and optimize sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Metabolism and Disposition Research: Facilitates studies on the metabolic pathways and stability of proguanil in vitro and in vivo.
• Clinical Trial Support: Critical for the accurate quantification of drug and metabolite levels in patient samples during clinical trials for malaria treatment.
• Reference Material for Quality Control: Serves as a high-purity certified reference material (CRM) for calibrating instruments and ensuring data integrity in pharmaceutical QC labs.

Basic Information

Product Name	Cycloguanil-D4 Hydrochloride
CAS No.	1189427-23-3
Molecular Formula	C11H12D4ClN5•HCl
Molecular Weight	290.20 g/mol (approx.)
Synonyms	1-(4-Chlorophenyl)-2,2-dimethyl-4,6-diamino-1,2-dihydro-1,3,5-triazine-d4 Hydrochloride; 4,6-Diamino-1-(4-chlorophenyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine-d4 Hydrochloride; Cycloguanil-d4 HCl; Chloroguanide Triazine Metabolite-d4 Hydrochloride; Proguanil Metabolite-d4 HCl; BRL 50921-d4 Hydrochloride
EINECS	Contact for details

Quality Control

Our Cycloguanil-D4 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), isotopic enrichment, and other critical parameters. We support research and development that demands reliable and traceable reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.