Description

2-(2-Fluoro-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable synthesis of fluorinated and nitrated aromatic intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated aromatic rings, leveraging the Suzuki reaction for carbon-carbon bond formation.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the specific substitution pattern (fluoro and nitro groups) imparts desired biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are incorporated to tune electronic properties.
• Chemical Biology Probes: Utilized in the creation of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D pipelines.

Basic Information

Product Name	2-(2-Fluoro-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1189042-70-3
Molecular Formula	C12H15BFNO4
Molecular Weight	279.07 g/mol
Synonyms	2-Fluoro-3-nitrophenylboronic acid pinacol ester; (2-Fluoro-3-nitrophenyl)boronic acid pinacol ester; 2-(2-Fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-fluoro-3-nitrophenyl)boronate; 2-Fluoro-3-nitrobenzeneboronic acid pinacol ester; 2-Fluoro-3-nitrophenyl-Bpin; B-(2-Fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks for chemical substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.