Description

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl][bis(trifluoromethyl)sulfonylimido]gold(I) is a highly specialized, air-stable gold(I) complex featuring a privileged Buchwald-type phosphine ligand and a weakly coordinating anion. This compound is engineered to serve as a precise and efficient catalyst precursor for demanding cross-coupling and C-H activation reactions. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high catalytic activity and selectivity under mild conditions.

Application

• Pharmaceutical Intermediate Synthesis: As a catalyst for C-N, C-O, and C-C bond-forming reactions in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Facilitating the construction of novel heterocyclic compounds and complex molecular architectures for crop protection agents.
• Materials Science: Enabling the synthesis of conjugated polymers, organic semiconductors, and specialty monomers through efficient cross-coupling methodologies.
• Academic & Industrial R&D: A critical tool for methodological development in organic synthesis, particularly for challenging substrates.
• Catalyst Screening Libraries: Used as a high-performance component in catalyst kits for reaction optimization and discovery chemistry.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl][bis(trifluoromethyl)sulfonylimido]gold(I)
CAS No.	1188507-66-5
Molecular Formula	C33H41AuF6NO4P1S1
Molecular Weight	915.68 g/mol
Synonyms	JohnPhosAuNTf2; (2-Biphenyl)di-tert-butylphosphine Gold(I) Triflimide Complex; [Au(JohnPhos)(NTf2)]; Gold(I) JohnPhos Triflimide; (2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl)gold(I) triflimide (common mis-assignment); (2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl)((trifluoromethyl)sulfonyl)imide gold; Au(I)-JohnPhos-NTf2; Gold catalyst with BrettPhos-type ligand.
EINECS	Contact for details

Quality Control

Every batch of our gold(I) catalyst is produced and analyzed under strict inert atmosphere conditions to guarantee purity and catalytic performance. We employ advanced analytical techniques including NMR (1H, 31P, 19F), HPLC, and elemental analysis to verify chemical identity and assay. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic and sensitive to oxidation; prolonged exposure to air or moisture will degrade performance. Keep the original container sealed and allow it to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Gold (Au) Content	21.0 - 22.0 %
Moisture (KF)	≤ 0.5 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.