Description

n-(5-Fluoro-3-Formylpyridin-2-Yl)Pivalamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyridine core functionalized with fluoro and formyl groups. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the final stages or penultimate steps for constructing the core pharmacophore of target molecules.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Product Name	n-(5-Fluoro-3-Formylpyridin-2-Yl)Pivalamide
CAS No.	1188433-81-9
Molecular Formula	C11H13FN2O2
Molecular Weight	224.23 g/mol
Synonyms	2-Pivalamido-5-fluoro-3-pyridinecarboxaldehyde; 5-Fluoro-3-formyl-2-pivalamidopyridine; 2-(Pivalamido)-5-fluoro-3-pyridinecarbaldehyde; N-(5-Fluoro-3-formyl-2-pyridinyl)-2,2-dimethylpropanamide; Pivalamide, N-(5-fluoro-3-formyl-2-pyridinyl)-; 1188433-81-9; 5-Fluoro-2-(pivalamido)nicotinaldehyde
EINECS	Contact for details

Quality Control

Our n-(5-Fluoro-3-Formylpyridin-2-Yl)Pivalamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, NMR, and MS. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.