Description

Nifedipine-D6 CAS NO 1188266-14-9 is a deuterium-labeled analog of the widely used calcium channel blocker nifedipine. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities for applications requiring precise internal standards.

Application

• Internal Standard for Bioanalytical Assays: Used in LC-MS/MS and GC-MS methods for the accurate quantification of nifedipine in biological matrices (plasma, serum, urine) during pharmacokinetic and toxicokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Facilitates the study of absorption, distribution, metabolism, and excretion (ADME) profiles of nifedipine.
• Pharmaceutical Quality Control (QC): Serves as a critical reference standard in the analysis of drug substance and finished product purity and stability.
• Clinical Research: Enables precise monitoring of drug levels in patient samples during clinical trials for hypertension and angina.
• Forensic and Anti-Doping Analysis: Provides a reliable isotopic standard for the confirmatory analysis of nifedipine in forensic toxicology and sports doping control.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.

Basic Information

Item	Detail
Product Name	Nifedipine-D6
CAS No.	1188266-14-9
Molecular Formula	C17H12D6N2O6
Molecular Weight	~348.35 g/mol
Synonyms	Nifedipine-d6; 3,5-Dimethyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate-d6; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester-d6; Deuteronifedipine; Nifedipine (hexadeuterated); Bay a 1040-d6; Adalat-d6; Procardia-d6; [2H6]-Nifedipine
EINECS	Contact for details

Quality Control

Our Nifedipine-D6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation (NMR, MS). We adhere to relevant industry standards for reference materials to support your compliance with GMP, GLP, and ICH Q2(R1) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.