Description

Zonisamide-13C2-15N is a stable isotope-labeled analog of the anticonvulsant drug Zonisamide, specifically labeled with carbon-13 and nitrogen-15 at key molecular positions. This compound is an essential internal standard for the precise quantification and pharmacokinetic profiling of Zonisamide in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and diagnostic manufacturers engaged in bioanalytical method development, clinical trial studies, and drug metabolism research.

Application

• Bioanalytical Method Development: Serves as a critical internal standard for developing and validating sensitive and specific LC-MS/MS methods for Zonisamide quantification.
• Clinical Pharmacology & Pharmacokinetics (PK): Enables accurate measurement of Zonisamide concentrations in plasma, serum, and other biological fluids during clinical trials.
• Drug Metabolism and Disposition (DMPK): Used in mass spectrometry-based studies to investigate the metabolic pathways and clearance mechanisms of Zonisamide.
• Therapeutic Drug Monitoring (TDM): Facilitates the precise calibration of assays used to monitor Zonisamide levels in patient samples for optimal dosing.
• Forensic and Toxicology Analysis: Supports accurate identification and quantification of Zonisamide in complex forensic or toxicological casework.
• Reference Material for Quality Control: Acts as a certified reference material for quality assurance and control in analytical testing laboratories.

Basic Information

Product Name	Zonisamide-13C2-15N
CAS No.	1188265-58-8
Molecular Formula	C8H8N2O3S (with 13C2, 15N labeling)
Molecular Weight	Approx. 214.2 g/mol (Contact for exact isotopic weight)
Synonyms	1,2-Benzisoxazole-3-methanesulfonamide-13C2-15N; 3-(Sulfamoylmethyl)-1,2-benzisoxazole-13C2-15N; Zonisamide (13C2,15N); Zonisamide Isotopically Labeled; Zonisamide Internal Standard; [13C2,15N]-Zonisamide; CI-912-13C2-15N; AD-810-13C2-15N
EINECS	Contact for details

Quality Control

Every batch of Zonisamide-13C2-15N is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Comprehensive characterization is performed using NMR, HPLC, and mass spectrometry to confirm structure, isotopic enrichment, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data including assay, isotopic purity, and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.