Description

Desmethyl Sibutramine-D7 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for metabolic and pharmacokinetic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development and quality control for related active pharmaceutical ingredients.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of sibutramine and its metabolites.
• Critical component in bioanalytical method development and validation for clinical and preclinical studies.
• Essential for conducting pharmacokinetic (PK) and metabolism studies to understand drug absorption, distribution, metabolism, and excretion (ADME).
• Used in forensic and anti-doping analysis to accurately identify and quantify controlled substances in complex biological matrices.
• Supports pharmaceutical quality control and stability testing of drug substances and products.
• Facilitates research into the biochemical pathways and mechanisms of action of related compounds.

Basic Information

Product Name	Desmethyl Sibutramine-D7 Hydrochloride
CAS No.	1188265-54-4
Molecular Formula	C16H19D7Cl2N
Molecular Weight	312.34 g/mol
Synonyms	N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine-d7 Hydrochloride; 1-(4-Chlorophenyl)-1-cyclobutyl-3-methylbutyl(methyl)amine-d7 Hydrochloride; Desmethylsibutramine-d7 HCl; Sibutramine Metabolite M2-d7 Hydrochloride; M2-d7 HCl; [2-([1-(4-Chlorophenyl)cyclobutyl]methyl)-N-methylpropan-1-amine-1,1,2,3,3,4,4-d7] Hydrochloride
EINECS	Contact for details

Quality Control

Our Desmethyl Sibutramine-D7 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.