Description

10,11-Dihydro-10-Hydroxy Carbamazepine-D4 (Rac-Licarbazepine-D4) is a deuterated analog of the active metabolite of the anticonvulsant drug carbamazepine. This stable isotope-labeled compound is essential for precise and reliable quantitative analysis in pharmacokinetic and metabolic studies. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical industry, ensuring accurate measurements of drug concentrations and metabolite profiles. The product is supplied with a CAS number of 1188265-49-7.

Application

• Internal Standard for Bioanalytical Assays: Primary use in LC-MS/MS and GC-MS methods for the quantification of licarbazepine and related metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for carbamazepine and its derivatives.
• Drug Metabolism and Disposition Research: Used to elucidate metabolic pathways and identify specific metabolites in preclinical and clinical development.
• Pharmaceutical Quality Control (QC): Supports method development and validation for the assay of active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Trial Support: Critical for ensuring data integrity in therapeutic drug monitoring (TDM) studies and clinical trials involving antiepileptic drugs.
• Reference Material for Forensic Analysis: Used as a certified reference standard in forensic toxicology to confirm the presence of carbamazepine-related compounds.

Basic Information

Product Name	10,11-Dihydro-10-Hydroxy Carbamazepine-D4 (Rac-Licarbazepine-D4)
CAS No.	1188265-49-7
Molecular Formula	C15H8D4N2O2
Molecular Weight	256.30 g/mol (approx.)
Synonyms	10,11-Dihydro-10-hydroxycarbamazepine-d4; Licarbazepine-d4; Oxcarbazepine Metabolite-d4; 10-Hydroxy-10,11-dihydrocarbamazepine-d4; (10RS)-10,11-Dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide-d4; Rac-10-Hydroxy Carbamazepine-d4; MHD-d4 (10-Monohydroxy Derivative-d4)
EINECS	Contact for details

Quality Control

Every batch of 10,11-Dihydro-10-Hydroxy Carbamazepine-D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for isotopic enrichment, chemical purity (by HPLC), and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.