Description

5-Hydroxy Propafenone Hydrochloride-D5 is a deuterium-labeled analog of the primary metabolite of the Class IC antiarrhythmic drug, propafenone. This stable isotope-labeled compound is essential for conducting precise pharmacokinetic and metabolic studies, ensuring accurate quantification and reliable data. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical reference standard manufacturers for use as an internal standard in LC-MS/MS and GC-MS bioanalytical methods.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in quantitative LC-MS/MS and GC-MS methods for the determination of propafenone and its metabolites in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracing and quantification of the 5-hydroxypropafenone metabolite during ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial bioanalysis to understand patient variability in drug metabolism.
• Reference Standard: Used as a certified reference material (CRM) to validate analytical methods and ensure the accuracy and precision of test results.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of related substances and degradation products in drug substance and product development.

Basic Information

Product Name	5-Hydroxy Propafenone Hydrochloride-D5
CAS No.	1188265-48-6
Molecular Formula	C21H22D5ClNO3 • HCl
Molecular Weight	~424.4 g/mol
Synonyms	5-Hydroxypropafenone-d5 Hydrochloride; 1-[2-Hydroxy-3-(propylamino)propoxy]-5-hydroxy-2-(deuteriomethyl-2,3,4,5,6-d5)phenyl]-3-phenyl-1-propanone Hydrochloride; 5-OH-Propafenone-D5 HCl; Deuterated 5-Hydroxy Propafenone HCl; Propafenone Metabolite D5 Hydrochloride; 5-Hydroxypropafenone (phenyl-d5) Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy Propafenone Hydrochloride-D5 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity (D-content), chemical purity (HPLC), and identity confirmation (NMR, MS). Our standards are suitable for use in GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) compliant environments, ensuring reliable and reproducible results for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.