Description

Midodrine-D6, Hydrochloride is a stable isotope-labeled analog of the active pharmaceutical ingredient Midodrine, where six hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring accurate and reliable quantitative analysis in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for applications requiring the highest level of precision. The compound is supplied as a high-quality material suitable for use in method development, validation, and quality control processes.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference in bioanalytical studies for Midodrine pharmacokinetics, bioavailability, and bioequivalence.
• Metabolite Profiling and Identification: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and identify metabolite pathways.
• Pharmaceutical Quality Control (QC): Employed in the development and execution of validated analytical methods to assay Midodrine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research and Forensic Toxicology: Enables precise measurement of Midodrine concentrations in human plasma, serum, or urine for clinical trial monitoring or forensic investigations.
• Stability-Indicating Method Development: Acts as a stable reference point in assays designed to detect and quantify degradation products in drug substances and products.

Basic Information

Product Name	Midodrine-D6, Hydrochloride
CAS No.	1188265-43-1
Molecular Formula	C12H12D6ClNO3 • HCl
Molecular Weight	308.23 g/mol (approx.)
Synonyms	Midodrine-d6 HCl; 2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide-d6 hydrochloride; (±)-Midodrine-d6 hydrochloride; ST 1085-d6; Ametrine-d6; Gutron-d6; Glymidodrine-d6; (RS)-Midodrine-d6 hydrochloride; 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol-d6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Midodrine-D6, Hydrochloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with the high-purity standards required for analytical reference materials. Certificates of Analysis (COA) are provided, detailing key parameters such as isotopic purity, chemical purity, and residual solvent content to support your regulatory submissions and internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a cool, dry place after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.