Description

Didesmethyl Sibutramine-D7 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and forensic toxicology. This stable isotope-labeled compound is essential for ensuring the precision and reliability of mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and regulatory bodies involved in the development and quality control of pharmaceutical substances.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of sibutramine and its metabolites in complex biological matrices.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of sibutramine-related compounds.
• Forensic and Clinical Toxicology: Enables accurate detection and measurement of sibutramine in urine, blood, or plasma samples for doping control and adulterated product analysis.
• Method Development and Validation: A key component in developing and validating robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Reference Material for Quality Control: Acts as a certified reference material (CRM) to calibrate equipment and verify assay accuracy in quality control laboratories.

Basic Information

Product Name	Didesmethyl Sibutramine-D7 Hydrochloride
CAS No.	1188263-87-7
Molecular Formula	C15H17D7ClN
Molecular Weight	279.86 g/mol
Synonyms	1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-cyclobutanemethanamine-d7 Hydrochloride; Sibutramine Desmethyl Metabolite-d7 HCl; Didesmethylsibutramine-d7 HCl; DDS-d7 Hydrochloride; Didesmethyl Sibutramine D7 HCl; Didesmethyl Sibutramine (D7) Hydrochloride; Didesmethyl Sibutramine-d7 Hydrochloride
EINECS	Contact for details

Quality Control

Our Didesmethyl Sibutramine-D7 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D7), and chemical purity. We provide a comprehensive Certificate of Analysis (COA) detailing all specifications, including assay, impurity profile, and residual solvent content, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.