Description

Tizanidine-D4 Hydrochloride is a high-purity, isotopically labeled internal standard essential for precise quantitative analysis in modern laboratories. This deuterated compound is critical for ensuring accuracy and reliability in sensitive analytical methods, particularly mass spectrometry. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of Tizanidine in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Supports drug metabolism and pharmacokinetics (DMPK) studies, enabling precise tracking of the parent drug.
• Bioanalytical Method Validation: Critical for developing and validating robust, GLP-compliant analytical methods for clinical and preclinical trials.
• Forensic and Toxicology Analysis: Employed in forensic laboratories for the definitive identification and quantification of Tizanidine in forensic casework.
• Quality Control in Manufacturing: Can be used in impurity profiling and stability-indicating assay methods for pharmaceutical quality control.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based studies.

Basic Information

Product Name	Tizanidine-D4 Hydrochloride
CAS No.	1188263-51-5
Molecular Formula	C9H8D4ClN5S
Molecular Weight	257.76 g/mol
Synonyms	5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine-d4 hydrochloride; 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole-d4 hydrochloride; Zanaflex-d4 HCl; Sirdalud-d4 HCl; Tizanidine (phenyl-d4) hydrochloride; Tizanidine-d4 HCl; [2H4]-Tizanidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Tizanidine-D4 Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and chromatographic data is provided with each shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.