Description

4-Acetaminophen-D3 Sulfate Potassium Salt is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in LC-MS/MS method development and validation.

Application

• Internal Standard for LC-MS/MS Analysis: Used for the precise quantification of acetaminophen (paracetamol) and its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical reference standard for developing and validating robust, sensitive, and specific analytical methods.
• Therapeutic Drug Monitoring (TDM): Supports assays designed to monitor acetaminophen levels in patients to ensure therapeutic efficacy and prevent toxicity.
• Forensic and Toxicology Testing: Employed in laboratories analyzing overdose cases or conducting forensic investigations involving acetaminophen.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability studies of acetaminophen-containing drug products.

Basic Information

Product Name	4-Acetaminophen-D3 Sulfate Potassium Salt
CAS No.	1188263-45-7
Molecular Formula	C8H5D3KNO5S
Molecular Weight	274.30 g/mol
Synonyms	Paracetamol-D3 Sulfate Potassium Salt; APAP-D3 Sulfate K Salt; N-(4-Hydroxyphenyl)acetamide-D3 Sulfate Potassium Salt; 4'-Hydroxyacetanilide-D3 Sulfate Potassium Salt; Deuterated Acetaminophen Sulfate Potassium Salt; Potassium (acetyl-2H3)aminophenol sulfate; Acetaminophen-d3 Sulfate Potassium
EINECS	Contact for details

Quality Control

Every batch of our 4-Acetaminophen-D3 Sulfate Potassium Salt is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results (HPLC, NMR, MS) is provided with each shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.