Description

(R)-(9H-Fluoren-9-Yl)Methyl 2-Methylpiperazine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical integrity is paramount for efficacy and safety. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Key Intermediate in API Synthesis: Serves as a crucial chiral precursor in the multi-step synthesis of complex, target-specific pharmaceutical compounds.
• Asymmetric Catalysis & Ligand Development: Used in the research and development of novel chiral catalysts and ligands for stereoselective transformations.
• Peptidomimetic & Scaffold Construction: Employed in medicinal chemistry for building constrained peptide mimics and privileged molecular scaffolds with defined stereochemistry.
• Process Chemistry & Scale-Up: Utilized in the optimization and commercial-scale production of drug candidates requiring the (R)-2-methylpiperazine moiety.
• Reference Standard & Analytical Testing: Functions as a high-purity reference standard for quality control and analytical method development (e.g., HPLC, chiral analysis).
• Academic & Contract Research: Supports academic research and contract research organizations (CROs) in exploratory chemistry and hit-to-lead optimization programs.

Basic Information

Item	Detail
Product Name	(R)-(9H-Fluoren-9-Yl)Methyl 2-Methylpiperazine-1-Carboxylate
CAS No.	1187930-73-9
Molecular Formula	C21H24N2O2
Molecular Weight	336.43 g/mol
Synonyms	(R)-Fmoc-2-Methylpiperazine; (R)-N-Fmoc-2-Methylpiperazine; (R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylpiperazine; (R)-2-Methyl-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazine; (R)-Fmoc-2-Methylpiperazine-1-carboxylate; (R)-1-[(9-Fluorenylmethyloxycarbonyl)]-2-methylpiperazine; (R)-N-α-Fmoc-2-methylpiperazine; (R)-Fmoc-2-MePip-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our (R)-(9H-Fluoren-9-Yl)Methyl 2-Methylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.