Description

4-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring both a boronic acid group and a trifluoromethyl-substituted phenol moiety. This unique structure makes it a highly valuable building block in modern synthetic chemistry, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors to introduce functionalized aromatic systems into complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring trifluoromethylated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves compound efficacy and environmental profile.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid partner for constructing biaryl and heterobiaryl structures in drug discovery and material science.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of advanced polymers with specific thermal, chemical, or surface properties.
• Diagnostic Reagent Manufacturing: Potential use in synthesizing probes and sensors for biochemical assays.
• Organic Electronic Materials: Investigated for the creation of novel materials for OLEDs, semiconductors, and other electronic applications.
• Chemical Biology & Proteomics: Used in the design of molecular tools and inhibitors for studying biological pathways.

Basic Information

Product Name	4-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1187874-94-7
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	[4-Hydroxy-3-(trifluoromethyl)phenyl]boronic acid; 3-Trifluoromethyl-4-hydroxyphenylboronic acid; 4-Hydroxy-3-trifluoromethylbenzeneboronic acid; (4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid; 2-Trifluoromethyl-4-boronophenol; 4-Borono-2-(trifluoromethyl)phenol; B-[4-Hydroxy-3-(trifluoromethyl)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.