Description

Des[3-[[(1-Carboxymethyl)Cyclopropyl]Methyl]Thio]-2-Propenyl Montelukast Mesylate is a key pharmaceutical intermediate and a derivative of the leukotriene receptor antagonist Montelukast. This compound matters for its critical role in the research and development of advanced therapeutic agents targeting respiratory conditions such as asthma and allergic rhinitis. Pharmaceutical manufacturers and advanced research institutions need this high-purity intermediate to ensure the efficacy and consistency of their final drug products.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of novel Montelukast analogs and next-generation leukotriene receptor antagonists.
• Active Pharmaceutical Ingredient (API) Research: Serves as a crucial building block in medicinal chemistry for developing new respiratory therapeutics.
• Process Development & Scale-up: Used in optimizing manufacturing routes for Montelukast-based drugs in pilot plants and commercial production.
• Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate leukotriene pathways and inflammatory responses.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Des[3-[[(1-Carboxymethyl)Cyclopropyl]Methyl]Thio]-2-Propenyl Montelukast Mesylate
CAS No.	1187586-82-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Montelukast Impurity; Montelukast Related Compound; Des[3-[[(1-Carboxyethyl)Cyclopropyl]Methyl]Thio]-2-Propenyl Montelukast Mesylate (common variant); (R,E)-2-(1-((1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-1-hydroxypropan-2-ylthio)methyl)cyclopropyl)acetic Acid Mesylate Salt; Leukotriene D4 Receptor Antagonist Intermediate; MK-0476 Intermediate
EINECS	Contact for details

Quality Control

Our Des[3-[[(1-Carboxymethyl)Cyclopropyl]Methyl]Thio]-2-Propenyl Montelukast Mesylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) documenting full compliance are provided with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.